Ripe Pomegranate Fruits

Potential of Punicalagin: A Polyphenol for Sexual Health, Immune Vigor, and More

Punicalagin, a lesser-known polyphenol residing within pomegranates and pomegranate juice, is a hidden gem in the world of biochemical allies. Consider it the dependable friend you can call at 2 AM, whether you need help burying a metaphorical "body" or, in this case, priming your reproductive system for optimal performance.

This unassuming polyphenol, in tandem with its metabolites, harbors a repertoire of talents that make it a true virtuoso:

  1. The Viagra Effect: Punicalagin shares similarities with Viagra, thanks to its ability to raise nitric oxide (NO) levels. Nitric oxide relaxes the smooth muscle fibers within penile arteries, facilitating increased blood flow to the nether regions. An intriguing double-blind crossover study with 61 male participants found that 47% reported improved erections with pomegranate/punicalagin.

  1. Supporting Vascular Health: Punicalagin is a potent NO booster. It not only widens blood vessels but also enhances circulatory function through its robust antioxidant properties. Multiple studies have demonstrated its capacity to improve blood flow and even reverse the growth of arterial plaque, essentially acting as a "roto-rooter" for improved circulation.

Additionally, robust vascular health translates to enhanced hydraulic functionality, meaning that clear and strong "hoses" (blood vessels) can deliver the pressure needed for elevating the male member skyward.

  1. Testosterone Guardian: Punicalagin and its metabolite stand as powerful inhibitors of aromatase activity, thwarting the conversion of testosterone into estrogen and naturally elevating testosterone levels. Studies indicate that punicalagin can increase testosterone levels by an average of 24%. It also prevents testosterone conversion into dihydrotestosterone (DHT), thereby maintaining a normal PSA level and promoting a healthy prostate while facilitating optimal urinary flow.

A New Superpower: Recent scientific revelations have expanded the repertoire of pomegranate/punicalagin. German researchers have uncovered its ability to instigate a continuous supply of rejuvenated T cells, the "bouncers" of the immune system. These immune sentinels patrol the body, identifying potential threats and maintaining order.

Hunting Down Old Mitochondria: What's vital to understand is that punicalagin doesn't work alone; it's not readily absorbed by the body. Instead, it undergoes conversion by gut bacteria into ellagic acid, which is further metabolized into compounds, including various types of urolithin (e.g., urolithin A, B, D). Urolithin, in particular, efficiently enters circulation through the colon, making it the unsung hero.

Urolithin's claim to fame is its ability to bolster the immune system through a process akin to "mitochondrial autophagy." It purges old mitochondria from T cells, rejuvenating these immune warriors to ensure their optimal function within the cellular "society."

The Ultimate Immune System Warrior: Urolithin intervention enables the transformation of T cells into "T memory cells." These immune superheroes possess the unique ability to "remember" pathogens they encounter. This translates to quicker, more potent responses when facing a recurrent threat.

How Much Punicalagin/Urolithin Do You Need? Where Do You Get It?

Pomegranate superfruit in white background

There's an age-related hiccup when it comes to urolithin production in the body. As we age, changes in the gut microbiome lead to reduced urolithin production—approximately half of what younger individuals produce.

Thankfully, ingesting pomegranate or punicalagin is a viable solution. German researchers have shown that this can effectively introduce urolithin to the body, where it collaborates synergistically with the immune system.

While drinking pomegranate juice may seem like the go-to solution, it's essential to note that commercial pomegranate juice doesn't contain significant amounts of punicalagin, as it primarily resides in the pomegranate's root, bark, and leaves—none of which are used in the production of commercial juice.

To ensure ample intake of punicalagin, ellagic acid, and urolithin, supplements can provide a convenient solution. Biotest, for instance, has harnessed the power of punicalagin in P-Well 4, a multifaceted supplement tailored for vascular sexual health, urinary tract support, prostate well-being, and now, immune enhancement. Each serving comprises 180 mg of punicalagin sourced from pomegranate, along with 30 mg of lycopene from natural tomato extract and 500 mg of cranberry whole fruit concentrate.

In summary, punicalagin and its impressive metabolic offspring offer a multifaceted approach to enhancing sexual health, supporting the immune system, and bolstering overall well-being. These benefits extend to both men and women, making it a valuable addition to your health regimen.

James Freeman


Liam Marshall, the friendly fitness coach, has spent 14 years sharing his love for sports and fitness. With degrees in sports science, he crafts workouts that fit like your favorite jeans. Beyond the gym, he organizes sports clinics and tech-savvy fitness apps that motivate people worldwide. He's all about making fitness doable for everyone, and it's not just about bodies – it's boosting confidence. In 2019, he scored the "Virginia Fitness Coach of the Year" award. Outside the fitness world, he loves family time and hikes in Shenandoah National Park. Liam's journey from a small-town fitness fan to a big-time coach is all about passion, inspiring people to see fitness as a body-and-mind thing. Catch him on Instagram to stay in the loop!